Migraine sufferers have been characterized as particularly “stress-sensitive”, and they tend to experience headaches following periods of increased psychological stress.  The biological mechanisms responsible for this unusual stress response are poorly understood. In particular, it’s unclear why migraineurs suffer from headaches in response to stress whole others no not. Several theories have implicated autonomic dysfunction—and in particular sympathetic hyper-reactivity to stress— as a way of explaining increased psychological stress reactivity found in migraineurs. Despite efforts to capture these patterns in laboratory stress settings, researchers have been largely unable to provide reliable evidence of autonomic hyper-reactivity to acute stress in this population. The present study pursued the alternative hypothesis that migraineurs have prolonged autonomic recovery following stress, along with decreased habituation to repeated stressors. We compared patterns of autonomic stress recovery and habituation in a sample of young adult migraineurs and healthy controls using a repeated intermittent stressor task and separate measures of sympathetic and parasympathetic function. In contrast to our predictions, which posited sustained sympathetic engagement and a possibly blunted parasympathetic rebound upon stressor cessation, we found that individuals with episodic migraine were largely indistinguishable from controls in their sustained stress responses. Unexpectedly, migraineurs demonstrated consistently stronger vagal withdrawal to repeated stressors than healthy controls. They also showed evidence of greater cognitive and emotional reactions than controls, primarily in the form of higher subjective stress and more negative appraisals of the stressor task itself.  While this is not the first study to report altered parasympathetic function in migraineurs, it is one of only a handful to assess these patterns in the context of acute laboratory stress exposure, and the only known study to report exaggerated parasympathetic withdrawal alongside reports of increased subjective stress and negative stress appraisals.